Figure 2.

AAV-miR-9-5p sponge-mediated miR-9-5p inhibition has no effect on hippocampal LTP. A, Luciferase assay showing that the miR-9-5p sponge specifically suppresses the activity of miR-9-5p (***p < 0.001, n = 4 per group, Tukey's multiple-comparisons test after significant 1-way ANOVA). B, Theta-burst LTP was comparable between control and miR-9-5p sponge. C, Summary graph represents the average EPSC amplitudes of the last 5 min recording in control and miR-9-5p sponge groups (control, n = 12 cells from 7 mice, miR-9-5p, n = 14 cells from 6 mice, unpaired 2-tailed t test, t₍₂₄₎ = 0.8454, p = 0.4062). Data are mean ± SEM.