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. 2016 Aug 24;36(34):8921–8935. doi: 10.1523/JNEUROSCI.0148-16.2016

Figure 1.

Figure 1.

β-Catenin induces Cyp1b1, but not Cyp1a1 expression. A, GO enrichment analysis of identified DEGs from Affymetrix transcriptome analysis of β-catenin WT and β-catenin KO ECs. GOCirle plot for BBB-relevant GO terms, representing upregulated or downregulated genes in β-catenin KO cells. B, Heatmap of selected genes from the Affymetrix transcriptome analysis of β-catenin WT and β-catenin KO ECs. Dot-plot represents Cyp1b1 downregulation in β-catenin KO ECs by 31-fold. C, qRT-PCR for Cyp1b1 and Ahr in β-catenin KO relative to β-catenin WT ECs (dashed line, n = 4). D, qRT-PCR for mouse or human Cyp1b1 and mouse Cyp1a1 in β-catenin WT, β-catenin KO, and β-catenin KO ECs reinfected with human Cyp1b1 (n = 3). **p < 0.01. ***p < 0.001.