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Cyp1b1 inhibition in vivo increases brain vessel permeability. A, Schematic description of Cyp1b1 inhibition in C57BL/6JRJ WT mice followed by tracer experiment. B, In vivo tracer experiment representing RFUs normalized to serum levels of kidney and brain homogenates for 0.4 kDa FTSC and TMR 3 kDa dextran (left). Normalized RFUs of brain homogenates of TMS-treated animals are shown as percentage relative to control animals (dashed line, right).
