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. 2016 Jun 15;36(24):6538–6552. doi: 10.1523/JNEUROSCI.2869-15.2016

Figure 2.

Figure 2.

Dendritic pathology of CA1 pyramidal neurons in Ndel1 CKO mice. A, Dispersed CA1 pyramidal neurons from 7-week-old Ndel1 CKO mice display dendritic pathology as revealed by Golgi staining. B, Imaris software-enabled reconstruction of individual CA1 hippocampal neurons from 9-week-old Ndel1 CKO mice and WT littermates, as well as from control Cre transgenic mice and mice with both Ndel1 LoxP alleles deleted at P17 (Deleted) but with no protein knockdown (Fig. 1B). C, Reduced total neuronal process length and reduced number of dendrites in CA1 pyramidal cells from Ndel1 CKO mice. Total neuronal process length: WT: 2522 ± 376 μm versus Ndel1 CKO: 1607 ± 387 μm; mean ± SD (n = 6 animals). **p < 0.005 (Student's t test). Total number of dendrites per pyramidal cell: WT: 44.0 ± 4.8 versus Ndel1 CKO: 27 ± 5.0; mean ± SD (n = 5 or 6 animals). ***p < 0.001 (Student's t test).