Figure 10.
The inhibition of Gpr17 increases the immature oligodendrocyte population at the demyelinating lesion after LPC injection. A, Immunofluorescent staining for NG2 was performed on brain sections of Gpr17+/+ (WT), Gpr17−/−, and Gpr17 cKO mice and WT mice treated with pranlukast (n = 5 animals per genotype). *p < 0.05, two-way ANOVA. B, Western blot analysis of cleaved caspase 3 in the brains from WT, Gpr17−/−, Gpr17fl/fl, and Gpr17 cKO mice at 8 weeks of age (n = 6 animals per genotype). Pran, Pranlukast; Dpi, day post injection.