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. 2016 Oct 12;36(41):10560–10573. doi: 10.1523/JNEUROSCI.0898-16.2016

Figure 2.

Figure 2.

Gpr17 is a transcriptional target of Olig2 in LPC-treated oligodendrocytes. A, Heat maps of the Olig2-binding signals in oligodendrocytes treated with vehicle (Veh) or LPC. Each line on the y-axis represents a genomic region of ±0.5 kb flanking the Olig2 peaks. B, Genomic distributions of the Olig2 peaks in oligodendrocytes treated with vehicle or LPC. TSS, Transcription start site; TTS, transcription termination site. C, GO analysis of the differentially Olig2-bound genes. D, Binding profiles of H3K27Ac around Olig2 summits in oligodendrocytes treated with vehicle or LPC. E, Top-ranking genes with differentially Olig2-bound peaks as determined by the Tags. F, Genome browser view of the distributions of Olig2 and H3K27Ac on Gpr17 and Olig2. G, Quantitative real-time PCR analysis of the Gpr17 and Olig2 mRNA levels in oligodendrocytes treated with vehicle or 12.5 mm LPC for 12 h. Data are means ± SEM from three independent experiments. **p < 0.01, ***p < 0.001, Student's t test. Veh, Vehicle.