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. 2016 Nov 2;36(44):11320–11330. doi: 10.1523/JNEUROSCI.1588-16.2016

Figure 3.

Figure 3.

NO inhibits hyperpolarization-activated cation currents. Left, A, B, Typical current traces evoked by 3 s voltage pulses ranging from −65 to −135 mV in the control condition (a), after 10 min of exposure to 500 μm l-arginine or 100 μm l-NAME (b), and after 10 min of exposure to 30 μm ZD7288 (c). Steady-state (Iss) and instantaneous (Iinst) Ih currents were obtained by digitally subtracting the current in the presence of ZD7288 from the currents obtained in the control and in the presence of l-arginine (Ad, Ae) or l-NAME (Bd, Be). A1, B1, Average Iinst (insets) and Iss voltage relationships under control condition (filled circles) and in the presence of l-arginine or l-NAME (open circles), respectively. *p < 0.05 (paired Student's t test). **p < 0.005 (paired Student's t test). ***p < 0.001 (paired Student's t test).