Figure 5.
NO modulates Ih current in isolated cells. A, Representative traces of Ih currents in an isolated MNC in a control condition (a), in the presence of 500 μm l-arginine (b) followed by ZD7288 (c). d, e, The subtracted currents, Ih. B, The I–V relationship shows a significant decrease of Ih current in the presence of l-arginine compared with the control group. C, Representative traces of Ih currents measured in a single neuron at −135 mV to illustrate the method used to calculate the activation time constant of Ih. A single exponential function was fitted to the data points and calculated accordingly. *p < 0.05 (paired Student's t test). **p < 0.005 (paired Student's t test).