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Nitrergic modulation on HCN channels is independent of cGMP. A, B, Representative Ih currents in control, in the presence of ODQ (30 μm), ODQ plus l-arginine followed by the specific inhibitor of Ih, ZD7288 (30 μm). A1, B1, I–V relationships of ZD7288-sensitive currents in the control and in the presence of 30 μm OQD. Even in the presence ODQ, l-arginine induced a significant decrease in Ih. *p < 0.05 (paired Student's t test). **p < 0.005 (paired Student's t test).
