Figure 4.

In vivo effects of PBS and KA-induced (2 and 10 mg/kg) seizures in rats studied for histology. Change in MAP (A) and HR (B), at 120 min after intraperitoneal PBS or KA (2 and 10 mg/kg) injection and percentage change in EEG activity (gamma wave frequency AUC), at 60 min (C) and 120 min (D) after intraperitoneal PBS or KA (2 and 10 mg/kg) injection in different groups of rats. In all groups, n = 5. Statistical significance was determined using one-way ANOVA followed by t tests with a Holm-Šídák correction. Data are mean ± SEM. **p ≤ 0.01 compared with vehicle control group. *p ≤ 0.05 compared with vehicle control group.