Skip to main content
. 2016 Jan 13;36(2):506–517. doi: 10.1523/JNEUROSCI.2584-15.2016

Figure 7.

Figure 7.

Representative Poincare plots illustrate the changes in QT interval (A) and PR interval (B) following KA-induced seizures in rats. A, Treatment with KA causes a dramatic dispersion in the QT interval (prolongation) and arrhythmic behavior in the heart rate (multiple ellipses) (II). In rats treated with the PACAP antagonist (PACAP(6–38)) or with the microglial antagonist minocycline, prolongation of QT interval and the dysrhythmia is abolished (III, IV). Following treatment with KYNA, the HR and QT are restored to normal (V). HR-triggered ECG was drawn before and after treatment and shown in the right side corner of each box. Continuous black and dotted red lines indicate pretreatment and post-treatment ECG, respectively. B, Induction of seizures with intraperitoneal KA injection shortened the PR interval (II) compared with vehicle control. RVLM microinjection of PACAP(6–38) (III), minocycline (IV), or KYNA (V) did not show changes in seizure-induced short PR interval; however, PACAP(6–38) (III) and minocycline (IV) showed more dispersed PR interval with multiple ellipses. Scale bars are in milliseconds.