General motor activities in noncarrier and A53T-Tg rats. A, B, Locomotion (number of square crossings per min; A) and rearing (number of times per min; B) scores in 4- to 16-month-old noncarrier (n = 6; open circles) and A53T-Tg (n = 12; filled circles) rats. C, Correlation between weight gain and locomotion in animals for PET experiments. *p < 0.05 (two-way ANOVA). Correlation coefficients (r), p values, and R2 values are shown adjacent to the scatter plot.