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. 2019 Jun 25;31(5):369–386. doi: 10.1089/ars.2018.7688

FIG. 1.

FIG. 1.

Cardiac repair of hCVPCs delivered to acutely infarcted mice hearts. (A) Schematic of cell transplantation and analysis. (B) Kaplan–Meier survival curves for MI mice. (C) LVEF, LVFS, and LVD measured by echocardiography. n = 7 (Sham), 13 (PM and hCVPCs), and 11 (hcFbs). (D) LVDP, LVEDP, LV maximum ascending rates of pressure (+dp/dt max) and SV measured by pressure–volume loop at day 28 post-MI. n = 5–8. (E) Representative LV ESPVR. (F) Representative cross-sectional images and quantitative data of hearts stained with Masson's trichrome at day 28 post-MI. n = 6–8. Scale bars, 1 mm. *p < 0.05, **p < 0.01, ***p < 0.001 versus the PM or as indicated; #p < 0.05, ###p < 0.001 versus hcFbs. ESPVR, end-systolic pressure–volume relationship; hcFb, human cardiac fibroblast; hCVPC, human cardiovascular progenitor cell; LV, left ventricle; LVD, left ventricular systolic dimension; LVDP, left ventricular developed pressure; LVEDP, left ventricular end-diastolic pressure; LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; MI, myocardial infarction; PM, Puramatrix™; SV, stroke volume.