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A proposed model for the cadioprotection of hESC-CVPCs in the mice model of acute MI. hESC-CVPCs implanted at acute phase of MI regulate immune regulatory activity, including the modulation of reparative macrophage polarization by activating STAT6 through at least secreted IL-4 and IL-13, which dominantly contributes to the cardioprotective effect of hESC-CVPCs in the infarcted hearts. hESC-CVPC, human embryonic stem cell-derived cardiovascular progenitor cell.
