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FTY720 administration reduces hepatic sphingolipid levels. Mice were fed and treated as described in Fig. 2. Lipids were extracted from livers and ceramides, monohexosylceramides, and sphingomyelins (A), as well as their dihydro counterparts (B) measured by LC/ESI/MS/MS. Data are total sphingolipid levels and are shown as box and whisker plots, n = 6–11 mice per group. ***P < 0.005.
