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Effects of FTY720 on the expression of sphingolipid metabolic genes, S1PRs, cytokines, and chemokines. Mice were treated as described in Fig. 2, livers were isolated, and mRNA levels of Cers1-6 genes (A), Sphk1, Sphk2, and S1pr1-5 genes (B), and cytokine and chemokine genes were determined by quantitative PCR and normalized to Gapdh. Data are means ± SEMs, n = 5–6 mice per group. *P < 0/05. ND, not detected.
