Table 1. Cbl-c mutations by tumor type in TCGA.
Cbl-c mutations were identified in the cBioPortal for Cancer Genomics database as indicated in the table.
| Cancer Type | N | Missense | Truncations | In-frame Indels | Other* |
|---|---|---|---|---|---|
| All Sites | 27,437 | 97 | 13 | 0 | 2 |
| Hematological | 1,393 | 7 | 0 | 0 | 0 |
| Lymphoid | 1164 | 7 | 0 | 0 | 0 |
| Myeloid | 229 | 0 | 0 | 0 | 0 |
| Solid Tumors | 26,044 | 90 | 13 | 0 | 2 |
| Aerodigestive | |||||
| Head and Neck | 827 | 1 | 0 | 0 | 0 |
| Nasopharyngeal | 56 | 0 | 0 | 0 | 0 |
| Salivary Gland | 214 | 0 | 0 | 0 | 0 |
| Lung (Non-Small Cell) | 2591 | 6 | 2 | 0 | 0 |
| Lung (Small Cell) | 190 | 1 | 0 | 0 | 0 |
| Mesothelioma | 109 | 0 | 0 | 0 | 0 |
| Esophagus | 557 | 4 | 0 | 0 | 0 |
| Stomach | 1267 | 7 | 1 | 0 | 0 |
| Liver | 983 | 4 | 0 | 0 | 0 |
| Ampullary Carcinoma | 160 | 2 | 0 | 0 | 0 |
| Cholangiocarcinoma | 91 | 0 | 0 | 0 | 0 |
| Gall Bladder | 32 | 0 | 0 | 0 | 0 |
| Pancreas | 832 | 0 | 0 | 0 | 0 |
| Colon | 1,462 | 11 | 3 | 0 | 0 |
| Brain | 3,200 | 9 | 0 | 0 | 0 |
| Breast Cancer | 4,110 | 5 | 2 | 0 | 0 |
| Endocrine/Neuroendocrine | |||||
| Adrenal Cortical | 92 | 0 | 0 | 0 | 0 |
| Thyroid | 516 | 0 | 0 | 0 | 0 |
| Pancreatic Neuroendocrine | 118 | 0 | 0 | 0 | 0 |
| Pheochromocytoma | 184 | 0 | 0 | 0 | 0 |
| Genitourinary | |||||
| Bladder | 705 | 1 | 0 | 0 | 0 |
| Kidney | 1,387 | 2 | 0 | 0 | 0 |
| Prostate | 2,470 | 3 | 0 | 0 | 0 |
| Testicular | 156 | 1 | 0 | 0 | 0 |
| Gynecological | |||||
| Ovary | 615 | 2 | 1 | 0 | 0 |
| Endometrial | 627 | 4 | 2 | 0 | 0 |
| Cervical | 309 | 2 | 1 | 0 | 0 |
| Sarcoma | 732 | 1 | 0 | 0 | 0 |
| Skin | |||||
| Melanoma | 900 | 23 | 1 | 0 | 2 |
| Squamous | 29 | 1 | 0 | 0 | 0 |
*Mutations in splice regions that could cause missplicing