Fig 5. In silico analysis of AWC^ON voltage response to current injection.

The stimulation protocol consists in one single 15 pA current step with a duration of 500 ms. The holding current is I_h = 0pA. A) WT Voltage response to 15 pA current injection. B-F) Normalized conductance for modeled currents. In these panels we report the time evolution of the normalized conductance of each modeled current for the WT current clamp simulation shown in panel A. The normalized conductance is defined as the product of the activation and inactivation variables of the considered ion current (e.g. for SHL1 $g_x/{\overline{g}}_x=m_{\text{SHL1}}^3(0.7h_{\text{SHL1}}^{\text{f}}+0.3h_{\text{SHL1}}^{\text{s}})$). Panels B and C show $g_x/{\overline{g}}_x$ for voltage-gated K⁺ currents, panel D for voltage-gated Ca²⁺ currents, and panels E and F for calcium-dependent K⁺ currents. The $g_x/{\overline{g}}_x$ values for CCA1, UNC2 and EGL19 currents are multiplied by -1 to reproduce the sign of the associated currents.