Table 1. List of modeled ion channels.
The modeled C. elegans ion channels (second column), grouped on the basis of ion selectivity (first column) are classified according to vertebrate homologues (third column) and corresponding nematode genes (fourth column). The fifth and the sixth columns report the gene expression in AWCON and RMD. The seventh column reports the references to experimental data used to model each channel type and the relative organism. The symbols denote the specific patch clamp recording conditions: • on dissected worm cultured myocytes [25], body wall muscles [15] or pharynx [36], *, ∘ and ⋄ respectively on Xenopus oocytes, HEK cells, and CHO cells expressing the desired genes. In the text, the genes encoding for the modeled channels and the corresponding channel proteins are reported in italic and capital letters, respectively (e.g egl-19 genes encode for EGL-19 channels). Further, we denote the current associated to a specific class of channels with the channel protein name, omitting the dash between the gene family name and the number (e.g. EGL19 are the currents carried by EGL-19 channels). When two or more genes encode for a channel type, we indicate the channels and the currents with the gene family name in capital letters (e.g. kcnl-1/4, KCNL).
| Ion | Channel type | Vertebrate gene family | C. elegans gene | AWCON | RMD | Experimental data |
|---|---|---|---|---|---|---|
| K+ | Kv1,shaker | kcna | shk-1 | ✓ | ✓ | [25]: C.elegans•
[29]: Human* |
| Kv3,shaw | kcnc | egl-36 | - | ✓ | [30]: C.elegans* | |
| Kv4,shal | kcnd | shl-1 | ✓ | ✓ | [25]: C.elegans• | |
| Kvs-1 | kvs-1 | ✓ | - | [31]: C.elegans⋄ | ||
| Kv7 | kcnq | kqt-3 | ✓ | - | [26]: C.elegans* | |
| Kv10, eag | kcnh | egl-2 | ✓ | - | [28]: C.elegans* [32]: Drosophila* |
|
| Kir | kcnj | irk1-3 | ✓ | ✓ | [33]: C.elegans* [34]: Rat [35]: Aplysia californica |
|
| Ca2+ | CaV1, L-type | cacna | egl-19 | ✓ | ✓ | [15, 36]: C.elegans• |
| CaV2, P/Q-type | canca | unc-2 | ✓ | ✓ | [37]: Rat∘
[38]: Rat [39]: Mammalian∘ |
|
| CaV3, T-type | canca | cca-1 | ✓ | ✓ | [40]: Drosophila* | |
| K+ | KCa1.1, BK | slo1 | slo-1 | ✓ | ✓ | [41]: C.elegans* |
| BK | slo2, slack | slo-2 | ✓ | ✓ | [42]: C.elegans* | |
| KCa2, SK | kcnn | kcnl-1/4 | ✓ | ✓ | [43] No published patch clamp data |
|
| Na+ | NALCN | nalcn | nca-1/2 | ✓ | ✓ | [11, 12, 44] No published patch clamp data |