Table 1. Treponemal genomes analyzed in this study.

TP strain*	Place and year of isolation	Reference	GenBank Accession number, Genome sequence reference
TPA Nichols	Washington, D.C., USA; 1912	[42]	CP004010.2, [21,26]
TPA DAL-1	Dallas, USA; 1991	[43]	CP003115.1, [29]
TPA SS14	Atlanta, USA; 1977	[44]	CP004011.1, [24,26]
TPA Mexico A	Mexico City, Mexico; 1953	[41]	CP003064.1, [25]
TPA Chicago	Chicago; 1951	[41]	CP001752, [22]
TPE CDC-2	Akorabo, Ghana; 1980	[45]	CP002375.1, [19]
TPE Gauthier	Brazzaville, Congo; 1960	[46]	CP002376.1, [19]
TPE Samoa D	Apia, Samoa; 1953	[41]	CP002374.1, [19]
TPE Fribourg-Blanc	Guinea; 1966	[9,10]	CP003902.1, [12]
TEN Bosnia A	Bosnia; 1950	[47]	CP007548, [20]
TPeC Cuniculi A	unknown; before 1957	[41]	CP002103.1, [27]

*Additional genome sequences of TPE Ghana-051 and CDC 2575 became available recently [28] and TPA Sea81-4 was published as a whole genome sequence [23].