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. 2019 Jun 24;12(6):dmm036764. doi: 10.1242/dmm.036764

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Gata4^G295Ski/wt embryos exhibit a deficit in EMT in the pOFT. (A,B) Collagen explant assays of E10.5 pOFTs exhibit differences in EMT after 48 h of ex vivo culture between wild-type (A; n=11) and Gata4^G295Ski/wt embryos (B; n=9). White arrows indicate mesenchymal cells. (C) Although the total number of cells is not significantly different between wild type and Gata4^G295Ski/wt, the number of spindle-shaped mesenchymal cells is significantly decreased in G295S^ki/wt pOFT explants when compared with wild type (P-value=0.018). Consistent with this, the percentage of cells having undergone EMT is also significantly less in Gata4^G295Ski/wt explants compared with controls (P=0.0019). *P≤0.05, **P≤0.005, N.S., P>0.05 (Student's t-test). Scale bars: 100 μm.