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. 2019 Apr 1;146(12):dev174284. doi: 10.1242/dev.174284

Fig. 5.

Fig. 5.

Examination of the unique pattern of cell cycle exit and neurogenesis of thalamic progenitors. (A-D) t-SNE plots showing pseudotime (A), gene expression (B,C) and inferred cell cycle states (D) of cells originating from the caudal thalamus. The dashed arrow indicates the increase of pseudotime predicated by Monocle. (E,F) Temporal expression profiles of the genes that represent cell cycle and apical progenitors, IPCs (basal progenitors), and postmitotic neurons, respectively, in the caudal thalamus (E) and rostral pretectum (F). The arrowheads indicate the peak expression of genes representing the S (red) and M (blue) phases; the vertical dashed lines show the pseudotime position that corresponds to the peak of Neurog1/2 expression. (G) Heatmap showing the genes that are highly expressed in clusters 9 and 10. Cluster number is indicated at the top; clusters 15 and 16 are shown for comparison.