Table 1.
RNA-binding proteins act as either novel m6A readers or functional factors in m6A-induced RNA biology.
| RBPs | m6A reader | Binding site | Functions | Targets | Interacting molecules | References |
|---|---|---|---|---|---|---|
| eIF3 | + | 5ʹUTR | induces eIF4E-independent mRNA translation | [33] | ||
| IGF2BPs | + | 3ʹUTR | stabilizes RNA; impairs miRNA-induced RNA decay | MYC, Actin, Lin28, SRF | miRNAs | [39,43–45] |
| Prrc2a | + | CDS | stabilizes RNA | olig2 | [46] | |
| FMR1 | + | 3ʹUTR | inhibits translation; stabilizes RNA | Ythdf2 | [47–49] | |
| eIF3 | - | 5ʹUTR | aids Ythdf1 or Mettl3 to promote translation | Ythdf1, Mettl3 | [37,38] | |
| ABCF1 | - | 5ʹUTR | aids eIF4F-independent mRNA translation | Hsp70 | Mettl3 | [34] |
| HuR/ELAVL1 | - | 3ʹUTR | stabilizes RNA | IGFBPs, FOXM1, SOX2 | miRNAs | [50–53,55–57] |
| RNAPII | - | regulate translation efficiency | PCIF1, MTC | [36,59] | ||
| XRN1 | - | aids Ythdc2 to stabilize RNA | Ythdc2 | [60] | ||
| DDX3 | - | aids Alkbh5 to erase m6A | Alkbh5, AGO2 | [61] | ||
| DDX46 | - | regulates nuclear export | MAVS, TRAF3, TRAF6 | Alkbh5 | [62] | |
| RdRp-3D | - | aids viral replication | Mettl3 | [63,64] | ||
| PARP | - | 5ʹUTR | aids DDR | Mettl3, Pol κ | ||
| MazF | - | cleaves specific RNA sequence without m6A | [65] | |||
| CEBPZ | - | CCAAT-box | activates transcription | SP1 | Mettl3 | [73] |
| SRSF2 | - | ESE | regulates pre-mRNA alternative splicing | RUNXITI | FTO | [68,69] |
| SRSF3 | - | 3ʹUTR | regulates pre-mRNA alternative splicing; export adaptor | Ythdc1 | [7,70] | |
| NXF1 | - | export receptor | Ythdc1 | [70] | ||
| TREX | - | regulates nuclear export | Ythdc1 | [74] | ||
| G3BP1 | - | repelled by m6A and promotes mRNA stability | Ythdf1 | [37,49] |