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. 2019 Apr 29;47(W1):W81–W87. doi: 10.1093/nar/gkz310

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Candidate cluster types. 1,2,3,4: Grey/yellow: gene involved in protocluster A/B. (A) Chemical Hybrids. Since cluster type A and cluster type B share a CDS that defines those protoclusters, they are classified as ‘chemical hybrid’. (B) Interleaved: Since none of the protoclusters share any defining CDS with any other protocluster, it is not annotated as a chemical hybrid, even though the biosynthetic product may or may not be. The two protoclusters form an interleaved candidate clusters, since the core of A overlaps with the core of B. (C) Neighbouring: Neighbouring candidate clusters are defined if the neighbourhoods of two protoclusters but not their cores overlap. (D) Singles: If protoclusters don’t have any overlap/relation with other protoclusters, the term single candidate cluster is assigned.