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. 2019 May 8;47(W1):W43–W51. doi: 10.1093/nar/gkz337

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Overview of DrugComb portal and the workflow. Drug combination screen data can be uploaded by users or from the literature. Data curation includes standardization of compound and cell line names, harmonization of drug effects as percentage inhibitions compared to the DMSO negative control, and a simplified file format to facilitate data storage in the database. The web server aims to analyze the curated data to determine and visualize the sensitivity and synergy of drug combinations. External tools are provided for a network-centric representation of mechanisms of action of drug combinations, skeletal view of drug molecules, as well as predicted drug–target interactions.