Table 1.

The data statistics of the studies curated in DrugComb

Study	Number of drugs	Number of drug combinations	Number of cell lines	Number of tissues	Size of the full dose–response matrix
ALMANAC	103	303 737	60	10	4 × 4 or 6 × 4
ONEIL	38	92 208	39	6	5 × 5
FORCINA	1818	1818	1	1	2 × 2
CLOUD	283	40 160	1	1	2 × 2

The number of drug combinations was counted as one experiment where a drug combination has been tested for a particular cell line. For the ONEIL study, there are 583 unique drug combinations, where all of them have been tested in each of 39 cell lines, and therefore 583 × 39 = 22 737 drug combinations. All the drug combinations have been repeated multiple times including 22 422 drug combinations repeated four times while 315 drug combinations repeated eight times. Therefore, the total number of drug combination experiments sum up to 22 422 × 4 + 315 × 8 = 92 208 drug combinations. All the other studies have not provided the drug combinations that have been replicated on the exactly same concentrations.