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The detailed visualization of interfacial waters and contact atoms is displayed using the ‘Highlight Contact Residues’ and ‘Zoom In’ functions of AppA. As seen, the atom O of interfacial water HOH202 makes a hydrogen bond with the main chain atom N of His86 of antigen VEGF, and another hydrogen bond with the atom O of interfacial water HOH457. The atom O of HOH457 makes another hydrogen bond with the sidechain atom ND2 of Asn52 of Lucentis.
