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. 2019 Jun 27;178(1):216–228.e21. doi: 10.1016/j.cell.2019.05.025

Figure 4.

Figure 4

Structures of R5.004 and R5.016 Epitopes

(A) Structure of PfRH5ΔNL bound to R5.004 and R5.016 Fab fragments. Insets show close-up views of epitopes.

(B) The top PfRH5 peptides protected in HDX-MS by R5.004 mAb (blue) and R5.016 mAb (red) binding, are highlighted on the structure of PfRH5ΔNL. Positions of Fab fragments are overlaid as faded cartoons.

(C) Overlay of PfRH5ΔNL:BSG (PDB: 4U0Q, BSG in teal) with R5.004 Fab or R5.016 Fab structures at their respective binding sites in the PfRH5ΔNL:R5.004:R5.016 structure.

See also Figure S4 and Tables S2 and S3.