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Inhibition of epitope detection by mAb 3E10 (“anti-Ser2-P”) due to phosphorylations on nearby residues.
Four differently-modified CTD repeat peptides are indicated along bottom, with phosphate indicated by orange, black-outlined P. All peptides carry Ser2-P, but the extra phosphate on the doubly-modified peptides inhibits antibody reactivity. Thus changes in amount of Ser2-P on the three doubly-modified repeat sequences cannot be determined by this antibody.
