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. 2018 Dec 26;10(2):76–90. doi: 10.1080/21541264.2018.1556915

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — Summary of intrinsically disordered regions (IDRs) in kinase module subunits. a) Comparison of yeast (S. cerevisiae) Med12 and Med13 with human MED12 and MED13. Overall sequence identity is about 13% for yeast vs. human MED12 and MED13. b) Comparison of human MED12, MED12L and human MED13, MED13L. Not shown are CDK8, CDK19, and CCNC, which are largely structured, but each contains IDRs at their C-termini. Plots were generated with IUPred2A[152]; regions with values over 0.5 are considered disordered.