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Sequence alignment corresponding to the trp box in rat and human TRPV and TRPA1 channels.
Identical residues are highlighted in yellow and similar residues in blue. Tryptophan and glutamine residues in the middle of the trp box are only present in TRPV channels. The residue K710 in hTRPV1 and the corresponding residue in other TRP channels is highlighted in pink, notice that most channels, including TRPA1 have a positively charged residue in that position.
