Figure 1.

Action potential prolongation in Shaker flies and Kv1.1-deficient mice. (a) In mutant Shaker flies with the KS133 allele (Sh^KS133), the cervical giant fiber axon exhibits prolonged action potentials compared to normal wildtype (WT) flies due to delayed repolarization (images reproduced with permission of Mark Tanouye [20]). (b) In Kcna1^{–/ –} mice lacking Kv1.1 channels, atrial cardiomyocytes exhibit significantly prolonged action potentials reminiscent of findings in the Shaker flies (images reproduced with permission [58]).