Fig E1.

Kinetic immune response of nasal mediators induced by R848 nasal challenge in individual subjects. A-I, Immune response of individual subjects (n = 9) after saline (left panels) and R848 (middle panels) challenge. Of interest, the 3 volunteers with atopy had relatively enhanced type 1 interferon responses, although this study was not specifically powered to address this question. Grouped data (right panels) are displayed as geometric means and 95% CIs. Blue line, Saline; red line, R848. Paired t test on AUC of log₁₀-transformed values between 0 and 8 hours in individual subjects after nasal challenge was used. IFN-β values: n = 7. A, Volunteer with allergic rhinitis; H, healthy.