Table E2.
Nasal and systemic symptoms after R848 nasal challenge
| Subject code | Nasal symptoms | Fever >37.2°C | Myalgia | Fatigue | Headache | Comments |
|---|---|---|---|---|---|---|
| 13 | Nil | No | No | No | No | Asymptomatic |
| 15 | Nil | No | Yes | Yes | Yes | Fatigue for up to 36 h after challenge |
| 16 | Blocked nose | Yes | No | No | No | Nose blocked at 3 h after challenge for 1 h Temperature increase from 36.9°C to 37.4°C Asymptomatic |
| 25 | Blocked + itchy nose | Yes | Yes | Yes | Yes | Shivering soon after administration of R848 for 1.5 h Flu-like symptoms overnight with nasal symptoms |
| 28 | Nil | No | No | No | No | Asymptomatic |
| 30 | Nil | No | No | No | No | Asymptomatic |
| 31 | Nil | No | No | No | No | Asymptomatic |
| 35 | Nil | No | No | No | No | Asymptomatic |
| 53 | Nil | Yes | Yes | Yes | Yes | Flu-like symptoms for 24 h after challenge Temperature increased to 39.2°C Mild-to-moderate headache |