Figure 4. Time cells during the 10 s delay period did not distinguish between left-turn and right-turn trials in either control or mEC-lesioned rats.

(A) For each cell, firing rates were calculated for 500 ms bins throughout the 10 s delay interval of correct trials. The distribution of peak firing rates from all CA1 cells (left) and CA3 cells (right) from control and mEC lesioned rats is shown. Cells with peak rates > 2 Hz in at least one time bin were considered active during the delay. (B) Temporal firing patterns of all CA1 cells and CA3 cells that were active during the 10 s delay. Each row is the average firing rate for a single cell over one block, normalized to the cell’s peak rate. Cells are sorted by the time of the peak during the first block of left-turn trials. Color bars indicate the firing rate from 0 Hz in blue to the peak rate in red. (C) For each cell, the correlation between corresponding time bins over the 10 s delay (i.e., time bin correlation) was calculated between left-turn and right-turn trials within a block and between trials of the same type across the two blocks (n.s., two-way ANOVA with trial type and blocks as factors). Symbols and error bars are the mean ± SEM. Left versus right rate differences in delay were also calculated using 5 s increments (* p < 0.05, Mann-Whitney test). See also Figure S5 and Table S4.