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. 2019 Apr 30;10(4):e00020. doi: 10.14309/ctg.0000000000000020

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© 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 1. — Circulating Tfh cells have an activated phenotype in IgG4-SC/AIP. Circulating Tfh-cell phenotype was analyzed by flow cytometry. (a) Contour plot showing CXCR3 and CCR6 expression on CD45RA-CD4+CXCR5+ Tfh cells from a representative donor. Three populations within the Tfh cells were identified: CXCR3+CCR6− Tfh1 cells, CXCR3−CCR6− Tfh2 cells, and CXCR3−CCR6+ Tfh17 cells. Gating for PD1 high cells shown. (b) Dot plot showing the percentage of CD4+CXCR5+ cells in active IgG4-SC/AIP, inactive IgG4-SC/AIP, disease controls with PSC, and healthy donors (HCs). (c) Dot plot showing the percentage of Tfh1, Tfh2, and Tfh17 subsets of blood Tfh cells in the 4 groups. (d) Dot plot showing the percentage of Tfh1, Tfh2, and Tfh17 cells expressing PD-1 in the 4 groups. (e) Dot plot showing absolute numbers of Tfh1, Tfh2, and Tfh17 cells expressing PD-1 in active and inactive IgG4-SC/AIP and HC groups. Median shown for all plots, Mann-Whitney and ANOVA with multiple comparisons, P values: NS P ≥ 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. AIP, autoimmune pancreatitis; HC, healthy control; IgG4-SC, IgG4-related sclerosing cholangitis; PD-1, programmed cell death protein 1; PSC, primary sclerosing cholangitis; Tfh, T-follicular helper.