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. 2019 Apr 30;10(4):e00020. doi: 10.14309/ctg.0000000000000020

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© 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 2. — Circulating PD-1+ Tfh2 cells correlate with plasmablasts in active IgG4-SC/AIP. Circulating plasmablasts and Tfh cells were analyzed by flow cytometry. (a) Contour plot showing CD38+ CD20− on CD27+ CD19+(low) cells identifying a plasmablast population from a representative donor. (b) Dot plot showing the percentage of CD27++CD38++CD20−CD19low plasmablasts in active IgG4-SC/AIP and HC. Median values and Mann-Whitney P values as in Figure 1. Correlation plots showing (c) PD-1+ Tfh cells and (d) PD-1+ Tfh2 cells plotted against the percentage of plasmablasts. Spearman rank correlation (r) and P values are expressed as NS ≥ 0.05, *P < 0.05, **P < 0.01, and ***P < 0.001. AIP, autoimmune pancreatitis; HC, healthy control; IgG4-SC, IgG4-related sclerosing cholangitis; PD-1, programmed cell death protein 1; Tfh, T-follicular helper.