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. 2019 Apr 30;10(4):e00020. doi: 10.14309/ctg.0000000000000020

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© 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 6. — CD4+ T cells and Tfh cells are present in IgG4-RD tissue specimens and home to lymphoid follicles. Paraffin-embedded tissue specimens were stained for Tfh-cell markers. (a) Representative panels from patients with IgG4-SC/AIP stained for CD4 (liver, top left panel), CXCR5 (pancreas, top right panel), ICOS (pancreas, bottom left panel), and CXCL13 (pancreas, bottom right panel). Positively staining cells stain DAP-positive (brown). (b) Histogram shows the percentage of positively staining specimens for CD4+, CXCR5+, CXCR5+ICOS+, and CXCL13+ cells. Data from 12 patients with IgG4-SC/AIP (red bars) and 10 disease controls (gray bars). **P values as in Figure 2. AIP, autoimmune pancreatitis; DC, disease control; IgG4-RD, IgG4-related disease; IgG4-RI, IgG4–responder index; IgG4-SC, IgG4-related sclerosing cholangitis.