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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: J Physiol. 2019 Jun 2;597(13):3425–3439. doi: 10.1113/JP278025

Figure 5. Effect of GABAB receptor antagonist on muscular colonic afferent excitability.

Figure 5.

(A) Response of two muscular colonic afferents that responded differently to CGP55845 (CGP, 5 μM) with respect to changes in the number of stretch-evoked AP, threshold, and the mean peak firing frequency: (i) An increase in the stretch-evoked response in presence of CGP and (ii) no change in the stretch-evoked response in the presence of CGP. Baseline (Bsl) responses are shown in black while the response in the presence of CGP is shown in grey. The influence of 5 μM CGP on the excitability of colonic afferents is illustrated in pooled action potential (B), threshold (C) and peak mean firing frequency (D) data from units (n = 8) before (Bsl) and after application of the antagonist. * is p<0.05, paired t-Test.