Table 3.
Analysis of associations between PanC risk and the six SNPs in the dataset of PanScan and PanC4 studies.
| SNP rs ID# & genetic model |
Group | OR (95% CI)a | Pb | ||
|---|---|---|---|---|---|
| Genotype | Case (%) | Control (%) | |||
| MAP2 rs35075084 CT>Cb | |||||
| Additive | TT | 8221 (96.49) | 6798 (95.60) | 1.00 | -- |
| T- | 295 (3.46) | 310 (4.36) | 0.75 (0.64-0.89) | 0.0006 | |
| -- | 4 (0.05) | 3 (0.04) | 0.99 (0.22-4.44) | 0.9871 | |
| Trend test | 0.0008 | ||||
| Dominant | T-+-- | 299 (3.51) | 313 (4.40) | 0.75 (0.64-0.89) | 0.0007 |
| TP53 rs9895829 A>G | |||||
| Additive | AA | 7729 (90.56) | 6315 (88.62) | 1.00 | -- |
| AG | 788 (9.23) | 790 (11.09) | 0.83 (0.75-0.93) | 0.0006 | |
| GG | 18 (0.21) | 21 (0.29) | 0.73 (0.39-1.37) | 0.3285 | |
| Trend test | 0.0004 | ||||
| Dominant | AG+GG | 806 (9.44) | 811 (11.38) | 0.83 (0.75-0.92) | 0.0004 |
| PRKAG2 rs2727572 C>T | |||||
| Additive | CC | 2432 (28.50) | 2146 (30.00) | 1.00 | -- |
| CT | 4170 (48.87) | 3485 (48.72) | 1.09 (1.01-1.17) | 0.0283 | |
| TT | 1930 (22.62) | 1522 (21.28) | 1.17 (1.07-1.28) | 0.0008 | |
| Trend test | 0.0007 | ||||
| Dominant | CT+TT | 6100 (71.50) | 4980 (69.62) | 1.11 (1.04-1.19) | 0.0034 |
| PRKAG2 s34852782 TA>Tb | |||||
| Additive | AA | 4237 (49.98) | 3687 (51.98) | ||
| A- | 3492 (41.49) | 2893 (40.79) | 1.06 (0.99-1.13) | 0.1161 | |
| -- | 749 (8.83) | 513 (7.23) | 1.29 (1.15-1.46) | <.0001 | |
| Trend test | 0.0002 | ||||
| Dominant | A-+-- | 4241 (50.02) | 3406 (48.02) | 1.09 (1.02-1.16) | 0.0076 |
| RPTOR rs62068300 G>A | |||||
| Additive | GG | 4093 (47.97) | 3278 (46.00) | ||
| GA | 3639 (42.65) | 3116 (43.73) | 0.92 (0.86-0.98) | 0.0149 | |
| AA | 801 (9.39) | 732 (10.27) | 0.85 (0.76-0.95) | 0.0043 | |
| Trend test | 0.0009 | ||||
| Dominant | GA+AA | 4440 (52.03) | 3848 (54.00) | 0.91 (0.85-0.97) | 0.0026 |
| RPTOR rs3751936 G>C | |||||
| Additive | GG | 4887 (25.28) | 3886 (27.01) | 1.00 | -- |
| GC | 3119 (49.55) | 2710 (49.40) | 0.93 (0.87-1.00) | 0.0347 | |
| CC | 513 (25.17) | 512 (23.59) | 0.82 (0.72-0.93) | 0.0025 | |
| Trend test | 0.0009 | ||||
| Dominant | GC+CC | 3632 (74.72) | 3222 (72.99) | 0.91 (0.86-0.97) | 0.0051 |
Abbreviations: PanC: pancreatic cancer; SNP: single nucleotide polymorphism; OR: odds ratio; CI: confidence interval.
a
Obtained from Logistic regression models with adjustment for age, sex, and top five significant principal components.
b
Base deletion.