Table 4.
Combined risk genotypes of the six SNPs and the risk of pancreatic cancer.
| NUG | Group | OR (95% CI)a | Pb | |
|---|---|---|---|---|
| Case (%) | Control (%) | |||
| 0 | 1 (0.01) | 1 (0.01) | 1.00 | -- |
| 1 | 34 (0.40) | 50 (0.71) | 1.75 (0.11-29.08) | 0.6963 |
| 2 | 459 (5.44) | 467 (6.61) | 1.48 (0.94-2.34) | 0.0911 |
| 3 | 1738 (20.59) | 1571 (22.25) | 1.66 (1.07-2.59) | 0.0253 |
| 4 | 3014 (35.70) | 2626 (37.20) | 1.75 (1.12-2.72) | 0.0133 |
| 5 | 2450 (29.02) | 1836 (26.01) | 2.04 (1.31-3.18) | 0.0016 |
| 6 | 746 (8.84) | 509 (7.21) | 2.23 (1.42-3.51) | 0.0005 |
| Trend test | <.0001 | |||
| 0-4 | 5246 (62.14) | 4715 (66.78) | 1.00 | -- |
| 5-6 | 3196 (37.86) | 2345 (33.22) | 1.24 (1.16-1.32) | <.0001 |
Abbreviations: SNP: single nucleotide polymorphism; PanC: pancreatic cancer; NUG: number of unfavorable genotype; OR: odds ratio; CI: confidence interval.
a
Risk genotypes were rs35075084 TT, rs2727572 CT+TT, rs34852782 A-+--, rs9895829 AA, rs62068300 GG and rs3751936 GG.
b
Logistic regression analyses were adjusted for age, sex and the top five principal components.