[a] Masson’s Trichrome stained tissue sections of young and aged mice implanted with a 1 cm2 piece of pristine, coated (no cytokine), single and sequential MCP-1 and IL-4 eluting meshes, 90 days post-implantation. [b] Image analysis of capsule density [area %; b, e], capsule area [μm2; c, f] and total cell number [d, g] on single mesh fibers (20X) from young [b – d] and aged [e – g] mice. Bars represent the mean ± SEM. Statistical significance as (*) p < 0.05, (**) p < 0.01, (***) p < 0.001 and (****) p < 0.0001, using two-way ANOVA with Tukey’s test. All other differences are non-significant.