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MRAP (black), which acts as an anti-parallel homodimer (10), interacts with MC2R (grey) within the endoplasmic reticulum via its transmembrane domain. This heterotrimeric structure then traffics to the cell surface through a process dependent upon a 15 amino acid tyrosine rich region of the N-terminus of MRAP, where it is capable of recognising and responding to the ACTH peptide.
