Table 1.
Minimum Inhibitory Concentrations for β-Lactams and β-Lactam/β-Lactam Inhibitor Combinations
| MIC (µg/mL) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Strain | AMP | ATM | FEP | CZAa | C/T | MEM | CZA + ATMb | MEM + VABc | ATM + VABc |
| PA_HTX1 | ND | >256 | >256 | 128 | >256 | >32 | 8 | >32 | >256 |
| PA_HTX2 | ND | >256 | >16 | >256 | >256 | >32 | 4 | >32 | >256 |
| TG1 + pBA169 | 3 | 0.032 | 0.064 | 0.25 | 0.064 | 0.016 | ND | ND | ND |
| TG1 + pBA169::blaGES-19 | >256 | 1.5 | 1 | 4 | 0.125 | 0.012 | ND | ND | ND |
| TG1 + pBA169::blaGES-26 | >256 | 0.25 | 0.5 | 2 | 0.38 | 0.016 | ND | ND | ND |
| TG1 + pBA169::blaGES-19–26 | >256 | >256 | >256 | >256 | 48 | 2 | 2 | ND | 0.25 |
| TG1 + pBA169::blaOXA-2 | >256 | 0.094 | 0.5 | 0.125 | 0.125 | 0.064 | ND | ND | ND |
Abbreviations: AMP, ampicillin; ATM, aztreonam; C/T, ceftolozane/tazobactam; CZA, ceftazidime/avibactam; FEP, cefepime; MEM, meropenem; MIC, minimum inhibitory concentration; ND, not done; VAB, vaborbactam.
aPerformed by broth microdilution, all others performed by E-test.
bAvibactam 2.2 µg/mL, to mimic the mean steady-state nadir in human plasma.
cVaborbactam 2 µg/mL, to mimic the mean steady-state nadir in human plasma.