Table 3.
Microbiome Characteristics by Continuous Antibiotic Exposure in the Prior 7 Days
| Multivariable Analysis β Coefficient | ||||
|---|---|---|---|---|
| Variable | Bivariable Analysis | P | (95% CI) | P Value |
| Alpha diversitya | ||||
| Levofloxacin | 0.18 (0.03 to 0.34) | .02 | 0.03 (–0.11 to 0.18) | .63 |
| BSBL | –0.17 (–0.29 to –0.05) | .007 | –0.13 (–0.24 to –0.02) | .02 |
| Oral vancomycin | –0.24 (–0.34 to –0.14) | <.001 | –0.22 (–0.32 to –0.12) | <.001 |
| Bacteroidetes proportional abundance | ||||
| Levofloxacin | 0.17 (–0.30 to 0.64) | .71 | ||
| BSBL | –0.06 (–0.44 to 0.32) | .77 | ||
| Oral vancomycin | –1.03 (–1.24 to –0.82) | <.001 | ||
| Dominance by non-Bacteroidetes genus | ||||
| Levofloxacin | 0.81 (0.57 to 1.14) | .23 | ||
| BSBL | 1.14 (0.91 to 1.41) | .25 | ||
| Oral vancomycin | 2.07 (1.43 to 3.00) | <.001 |
Unless noted otherwise, data are presented as median (interquartile range).
Abbreviations: BSBL, broad-spectrum beta-lactam; CI, confidence interval.
aShannon’s alpha diversity.