Table 4.
Microbiome Characteristics by Continuous Antibiotic Exposure in the Prior 14 Days
| Bivariable Analysis | P Value | Multivariable Analysis | ||
|---|---|---|---|---|
| β Coefficient | β Coefficient | |||
| Variable | (95% CI) | (95% CI) | P Value | |
| Alpha diversitya | ||||
| Levofloxacin | 0.06 (–0.05 to 0.18) | .29 | ||
| BSBL | –0.08 (–0.17 to 0.00) | .053 | –0.07 (–0.15 to 0.00) | .052 |
| Oral vancomycin | –0.14 (–0.20 to –0.08) | <.001 | –0.14 (–0.19 to –0.08) | <.001 |
| Bacteroidetes proportional abundance | ||||
| Levofloxacin | –0.01 (–0.35 to 0.34) | .98 | ||
| BSBL | –0.02 (–0.27 to 0.24) | .88 | ||
| Oral vancomycin | –0.48 (–0.72 to –0.33) | <.001 | ||
| Dominance by non-Bacteroidetes taxon | ||||
| Levofloxacin | 0.96 (0.78 to 1.20) | .76 | ||
| BSBL | 1.05 (0.91 to 1.22) | .73 | ||
| Oral vancomycin | 1.56 (1.21 to 2.00) | .001 |
Unless noted otherwise, data are presented as median (interquartile range).
Abbreviations: BSBL, broad-spectrum beta-lactam; CI, confidence interval.
aShannon’s alpha diversity.