Figure 1.

Four state Markov model structure. No Vaccination, Subunit Vaccination, and Live Attenuated Vaccine differ in the rates at which individuals transition from the “No Herpes Zoster” state to the “Herpes Zoster” state. The reduction in herpes zoster incidence with vaccination depends on the initial vaccine efficacy (based on age of vaccination) and the number of years since vaccination (where the linear vaccine waning reduces efficacy each year). Abbreviations: HZ, herpes zoster; PHN, post-herpetic neuralgia.