Table 3.

The effect of sitagliptin and diets on body composition and energy balance in SD rats

Response variable	Con		Cho
	Vehicle	Sitagliptin	Vehicle	Sitagliptin
Body weight (g)	348.4 ± 13.23	340.1 ± 11.48	335.9 ± 5.91	340.1 ± 6.71
Lean Mass (%)	79 ± 0.37	78.6 ± 0.43	79.4 ± 0.77	78.5 ± 0.66
Adiposity (%)	4.8 ± 0.39	5.2 ± 0.45	5.2 ± 0.68	5.3 ± 0.83
Food intake (g/g BW/day)	0.08 ± 0.001	0.08 ± 0.001	0.08 ± 0.001	0.08 ± 0.002
Energy intake (Kcal/gBW/day)	0.23 ± 0.004	0.24 ± 0.004	0.23 ± 0.004	0.24 ± 0.006

SD rats were fed Con and Cho diets ad libitum from day 10 through day 35 as described in the Materials and Methods. Half the animals of each group were orally gavaged with vehicle and the remaining half with an aqueous suspension of sitagliptin (100 mg/kg/day) for the duration of the study

Body weight and composition were determined prior to being euthanized. The lean mass and adiposity were calculated as a percentage of body weight. Group means for food and energy intake per unit body weight were calculated for the 35-day experimental period. Sitagliptin and high Cho diet did not affect body weight, composition and energy balance significantly. All data are presented as the mean ± SEM (n = 8 per group)