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. 2019 Jul 1;9:9441. doi: 10.1038/s41598-019-45766-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Segmentation of the Tumor ROI (red) and Whole Gland (green) in T2w images for case 7 baseline (left) and follow-up (right) scans. Each slice pair was selected to match location. Top and bottom show consecutive slices going through the same tumor. The individual time points were segmented manually by the domain expert blinded to the other time point. Upon the review of the images corresponding to the time points side by side, it becomes apparent that the location of the segmented region is not consistent for the slice shown in the bottom row.