Table 2.

Association results of the genetic variants showing a nominal significant signal for fasting glucose change (p < 0.05) in known T2D or glycemic trait loci^a.

SNP	Chr	BPb	Locus	EAb	NEAb	EAFb	Beta	SE	P	Directionc	HetPVald	N	HetISq
Fasting glucose loci
rs6943153	7	50759073	GRB10	T	C	0.30	−0.044	0.01	0.002	-------+-	0.4257	13,800	1
rs11619319	13	27385599	PDX1	A	G	0.77	0.039	0.02	0.011	+++++−+++	0.6785	13,807	0
Type 2 diabetes loci
rs10965248e	9	22122878	CDKN2A/B	A	G	0.18	−0.040	0.02	0.019	?--+--+--	0.06878	12,523	47
HbA1c loci
rs2073285	17	73628956	TMC6	T	C	0.20	0.079	0.03	0.002	+?++?+?+?	0.05396	5,098	57
rs4783565	16	67307691	CDH3	A	G	0.32	0.043	0.02	0.006	?++++++?+	0.4491	11,356	0
rs579459	9	135143989	ABO	T	C	0.78	−0.041	0.02	0.008	------+-+	0.2827	13,779	18
rs11619319	13	27385599	PDX1	A	G	0.77	0.039	0.02	0.011	+++++−+++	0.6785	13,807	0
rs10823343	10	70761019	HK1	A	G	0.75	−0.037	0.02	0.039	-+-----??	0.3766	8,809	6.7

^aScott et al.¹³, Scott et al.¹⁵, Wheeler et al.¹⁶.

^bBP:Physical Position (base pair) in build 36. EA: effect allele, NEA: non-effect allele, EAF: effect allele frequency.

^cThe sign of EA effect and the order of Cohorts are BHS, COLAUS, DESIR, ERGO, FHS, HBCS, KORA, PREVEND, SARDIANA.

^dHetPVal: P-value for testing for heterogeneity.

^eUsing proxy SNP rs10965250 (r2 = 0.97 with rs10965248).